The author is like a “storyteller” of humans’ scientific exploration over 400 years, narrating the course of scientific development since Copernicus published his accurately and elegantly written On the Revolutions of the Heavenly Spheres, showcasing the glorious achievements of mankind, the vivid stories of science, how the modern scientific edifice was established, and the historical inevitability of the development of science. The book explores the nature of the scientific spirit and the forces that drive science. Meanwhile, it also introduces math, physics, chemistry, and biology. This book is characterized by its trustworthy historical materials, coherent ideas, and vivid narration, vividly portraying the grand history of humanity’s four centuries of scientific exploration.