This book takes intelligent manufacturing production line as the object and introduces the key technologies involved in the operation optimization of intelligent manufacturing production line, including real-time data acquisition of production line status and cloud-edge collaborative computing technology, integrated planning and optimization technology of mixed production tasks of production line, active perception and collaborative scheduling technology of production logistics of production line, intelligent monitoring and life prediction technology of tool wear status, error analysis/tracing and prediction technology of workpiece processing quality, comprehensive evaluation technology of health status of complex CNC machining equipment, etc. These key technologies are important components of realizing intelligent manufacturing production line and are the core technologies for building a self-organizing, self-learning, self-adaptive, and self-optimizing production system. This book can be used as an optional textbook for graduate students majoring in “intelligent manufacturing”, which plays an important guiding role for students to understand smart workshops and smart factories.